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  • DEPRESSION

    Cannabinoids promote hippocampus neurogenesis and produce anxiolytic- and antidepressant
    http://www.jci.org/cgi/content/full/115/11/3104
    Antidepressant-like activity by blockade of anandamide hydrolysis
    http://www.pubmedcentral.nih.gov/art…medid=16352709
    Decreased depression in marijuana users. (may need free registration)
    http://www.medscape.com/medline/abstract/15964704
    Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.
    http://www.cannabis-med.org/studies/…w.php?s_id=190
    Nabilone improves pain and symptom management in cancer patients
    http://www.cannabis-med.org/studies/…w.php?s_id=177
    The perceived effects of smoked cannabis on patients with multiple sclerosis.
    http://www.cannabis-med.org/studies/…ow.php?s_id=13
    Cannabis and Depression
    http://www.pacifier.com/~alive/cmu/d…d_cannabis.htm
    Association between cannabis use and depression may not be causal, study says
    http://www.cannabis-med.org/english/…l.php?id=177#4
    Marijuana use and depression among adults: Testing for causal associations.
    http://www.ncbi.nlm.nih.gov/sites/en…ubmed_RVDocSum
    Do patients use marijuana as an antidepressant?
    http://www.ncbi.nlm.nih.gov/sites/en…ubmed_RVDocSum
    Cannabis’ Acts as Antidepressant
    http://www.thehempire.com/index.php/…antidepressant
    Cannabis And Depression Research
    http://www.thehempire.com/index.php/…ssion_research
    Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons
    http://marijuana.researchtoday.net/a…/4/10/1460.htm
    Marijuana chemical may treat depression
    http://www.healthcentral.com/depress…193323-66.html
    Therapeutic Aspects of Cannabis and Cannabinoids
    http://www.ukcia.org/research/Thereputic/Therapeut.htm
    Treating depression with cannabinoids
    http://www.cannabis-med.org/english/nav/home-jcant.htm
    Animal research highlights a therapeutic potential of cannabinoids for the treatment of depression
    http://www.cannabis-med.org/english/…_2008_02_1.pdf Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L (full – 2010)http://www.ncbi.nlm.nih.gov/pmc/arti...0/?tool=pubmed
    Uni-Morbid and Co-Occurring Marijuana and Tobacco Use: Examination of Concurrent Associations with Negative Mood States (full – 2010)http://www.ncbi.nlm.nih.gov/pmc/arti...5/?tool=pubmed
    Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders? (full – 2010) http://www.scielo.br/pdf/rbp/v32s1/en_a04v32s1.pdf
    Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress (full - 2010)http://www.nature.com/npp/journal/v3...pp201099a.html
    Depression-resistant endophenotype in mice overexpressing cannabinoid CB2 receptors (full – 2010)http://www.ncbi.nlm.nih.gov/pmc/arti...report=classic
    Brain CB2 Receptors: Implications for Neuropsychiatric Disorders (link to PDF– 2010) http://www.mdpi.com/1424-8247/3/8/2517
    Genes differentially expressed in CB1 knockout mice: involvement in the depressive-like phenotype. (abst – 2010)http://www.ncbi.nlm.nih.gov/pubmed/20692131
    Gadolinium-HU-308-incorporated micelles. (full – 2011) http://www.ncbi.nlm.nih.gov/books/NB...d-Micelles.pdf
    Is lipid signaling through cannabinoid 2 receptors part of a protective system? (full – 2011)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062638/
    Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. (full – 2011)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085542/
    N-palmitoylethanolamide, an endocannabinoid, exhibits antidepressant effects in the forced swim test and the tail suspension test in mice. (full – 2011) http://www.if-pan.krakow.pl/pjp/pdf/2011/3_834.pdf
    Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21278728
    Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions Figure 1: n-3/n-6 PUFA dietary imbalance alters PUFAs level in mouse brain (charts – 2011) http://www.nature.com/neuro/journal/...n.2736_F1.html
    Endocannabinoid system dysfunction in mood and related disorders. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21916860
    Intense exercise increases circulating endocannabinoid and BDNF levels in humans - Possible implications for reward and depression (abst – 2011) http://www.psyneuen-journal.com/arti...stract?rss=yes
    Personalized medicine can pave the way for the safe use of CB₁ receptor antagonists (abst – 2011)http://www.ncbi.nlm.nih.gov/pubmed/21497918
    Cannabinoids and emotionality: a neuroanatomical perspective. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21827834
    Testing bidirectional effects between cannabis use and depressive symptoms: moderation by the serotonin transporter gene (abst – 2011)http://onlinelibrary.wiley.com/doi/1...380.x/abstract
    Deficiency of Dietary Omega-3 May Explain Depressive Behaviors (news - 2011) http://www.thefreelibrary.com/Defici...s.-a0248155576
    Omega-3 Fatty Acids Essential for Normal Regulation of Mood in the Brain (news – 2011) http://www.elements4health.com/omega...the-brain.html
    Scientific research reveals brain alterations linking omega 3 deficit with depression (news – 2011) http://www.alphagalileo.org/ViewItem...CultureCode=en
    Endocannabinoids: A healthy diet is good for LTD (news – 2011) http://www.lipidmaps.org/update/2011...l/nrn2998.html
    What An Expectant Mother Eats Affects Children’s Psychology in Later Life (news – 2011)http://nanopatentsandinnovations.blo...s-affects.html
    A Brain Wrought Without Omega-3 (news – 2011) http://www.schizophreniaforum.org/ne...il.asp?id=1646
    Omega-3 deficiency disrupts cannibinoid receptor function in brain (news – 2011) http://www.wellsphere.com/general-me...-brain/1347465
    Natural Herbs That Increase Serotonin (news – 2011) http://www.livestrong.com/article/53...ase-serotonin/
    Why Omega-3s Affect Your Mood (news – 2011) http://voices.yahoo.com/why-omega-3s...941.html?cat=5
    Research provides new clues to understand link between deficits of AGPO-3, depression (news – 2011) http://www.news-medical.net/news/201...epression.aspx
    High on Life? Medical Marijuana Laws and Suicide (full – 2012) http/ftp.iza.org/dp6280.pdf
    Serum contents of endocannabinoids are correlated with blood pressure in depressed women. (full – 2012) http/www.lipidworld.com/content/pdf/1476-511X-11-32.pdf
    Cannabis use and depression: a longitudinal study of a national cohort of Swedish conscripts (full – 2012) http/www.biomedcentral.com/1471-244X/12/112
    Cannabinoid Receptor Genotype Moderation of the Effects of Childhood Physical Abuse on Anhedonia and Depression. (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3706194/
    Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3481531/
    Effect of delta-9-tetrahydrocannabinol on behavioral despair and on presynaptic and postsynaptic serotonergic transmission. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22386778
    Nature Against Depression. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22414105
    Lower levels of cannabinoid 1 receptor mRNA in female eating disorder patients: Association with wrist cutting as impulsive self-injurious behavior. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22542985
    Expression pattern of the cannabinoid receptor genes in the frontal cortex of mood disorder patients and mice selectively bred for high and low fear. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22534181
    The combined effects of parental divorce and parental history of depression on cannabis use in young adults in France. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22682099
    Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes (abst – 2012) http/jop.sagepub.com/content/26/10/1391
    Opposing local effects of endocannabinoids on the activity of noradrenergic neurons and release of noradrenaline: relevance for their role in depression and in the actions of CB(1) receptor antagonists. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22990678
    Essential fatty acids and lipid mediators. Endocannabinoids (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22730630
    Smoking Cannabis Increases Risk of Depression in the Case of Genetic Vulnerability, Study Finds (news – 2012) http/www.sciencedaily.com/releases/2011/10/111010074853.htm
    Effect of dietary fat type on anxiety-like and depression-like behavior in mice (full – 2013) http/www.springerplus.com/content/2/1/165
    Cannabinoids, Neurogenesis and Antidepressant Drugs: Is there a Link? (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3648779/
    Translational evidence for the involvement of the endocannabinoid system in stress related psychiatric illnesses. (full – 2013) http/www.biolmoodanxietydisord.com/content/3/1/19
    Endocannabinoid system and mood disorders: Priming a target for new therapies. (full – 2013) http/www.sciencedirect.com/science/article/pii/S0278584612002801
    Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment. (abst – 2013) http/link.springer.com/article/10.1007%2Fs00213-013-2995-y
    Additive effect of rimonabant and citalopram on extracellular serotonin levels monitored with in vivo microdialysis in rat brain. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23562616
    A Randomized Double-blind, Placebo Controlled Trial of Venlafaxine-Extended Release for Co-occurring Cannabis Dependence and Depressive Disorders (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3636166/
    Entopeduncular nucleus endocannabinoid system modulates sleep-waking cycle and mood in rats. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23584096
    Can Marijuana Reduce Social Pain? (abst – 2013) http/spp.sagepub.com/content/early/2013/05/13/1948550613488949.abstract
    Sleep Quality Moderates the Relation between Depression Symptoms and Problematic Cannabis Use among Medical Cannabis Users. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23721537
    The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23743650
    The endocannabinoid system and emotional processing: A pharmacological fMRI study with Δ9-tetrahydrocannabinol (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23928295
    Cannabinoid Receptor Activation Prevents the Effects of Chronic Mild Stress on Emotional Learning and LTP in a Rat Model of Depression. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24141570
    Endocannabinoid Signaling in the Etiology and Treatment of Major Depressive Illness. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24180398
    The endocannabinoid system and its possible role in neurobiology of psychiatric disorders (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24326750
    Low frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24335217
    Testing bidirectional effects between cannabis use and depressive symptoms: moderation by the serotonin transporter gene (abst – 2013) http/onlinelibrary.wiley.com/doi/10.1111/j.1369-1600.2011.00380.x/abstract
    Study: THC Increases Brain Activity In Response To Positive Stimuli (news – 2013) http/blog.norml.org/2013/08/27/study-thc-increases-brain-activity-in-response-to-positive-stimuli/
    This bud’s for you: Marijuana identified as a buffer against loneliness, study suggests (news – 2013) http/o.canada.com/life/marijuana-can-act-as-buffer-against-loneliness-study-suggests/
    5 Health Benefits Of Cannabichromene (CBC) (news – 2013) http/www.leafscience.com/2013/09/21/5-health-benefits-of-cannabichromene-cbc/
    Antidepressants and Changes in Concentration of Endocannabinoids and Nacylethanolamines in Rat Brain Structures. (full – 2014) http/download.springer.com/static/pdf/559/art%253A10.1007%252Fs12640-014-9465-0.pdf?auth66=1395868546_998a8d5d87cb02529572689ff9 213e4a&ext=.pdf
    Genetic Variations in the Human Cannabinoid Receptor Gene Are Associated with Happiness (full – 2014) http/www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0093771
    Therapeutic benefits of cannabis: a patient survey. (full – 2014) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3998228/
    Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24476943
    Anti-depressive mechanism of repetitive transcranial magnetic stimulation in rat: The role of the endocannabinoid system. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24479995
    Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain depressed behavior in rats. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24583930
    Relationships between serotonergic and cannabinoid system in depressive-like behavior:a PET study with [11C]-DASB. (abst – 2014) http/onlinelibrary.wiley.com/doi/10.1111/jnc.12716/abstract
    Is there a role for palmitoylethanolamide in the treatment of depression? (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24630855
    Cannabinoid Type 1 Receptor Availability in the Amygdala Mediates Threat Processing in Trauma Survivors. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24820537
    The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24861565
    Stress regulates endocannabinoid-CB1 receptor signaling. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24882055
    β-Caryophyllene, a CB2 Receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24930711
    Therapeutic Potential of Inhibitors of Endocannabinoid Degradation for the Treatment of Stress-Related Hyperalgesia in an Animal Model of Chronic Pain (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25100669
    Cannabis use and suicidal ideations in high-school students (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25123343
    Cannabinoid Transmission in the Prefrontal Cortex Bi-Phasically Controls Emotional Memory Formation via Functional Interactions with the Ventral Tegmental Area (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25253856
    Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine (abst – 2014)http://www.ncbi.nlm.nih.gov/pubmed/25340977
    The Endocannabinoid/Endovanilloid System and Depression (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25426013
    Drug discovery strategies that focus on the endocannabinoid signaling system in psychiatric disease (abst – 2014)http://www.ncbi.nlm.nih.gov/pubmed/25488672
    The association between cannabis use and mood disorders: A longitudinal study (abst - 2014) http://www.ncbi.nlm.nih.gov/pubmed/25451420
    Neural Effects of Cannabinoid CB1 Neutral Antagonist Tetrahydrocannabivarin (THCv) on Food Reward and Aversion in Healthy Volunteers (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25542687
    Activating cannabinoid brain receptors could replace marijuana for anxiety treatment (news – 2014)http://www.medicalnewstoday.com/articles/286482.php
    Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity (full – 2015) http://onlinelibrary.wiley.com/doi/1...ipo.22344/full
    Differential proteomic analysis of the anti-depressive effects of oleamide in a rat chronic mild stress model of depression (abst – 2015)http://www.ncbi.nlm.nih.gov/pubmed/25641667
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