Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/arti...ihms275514.pdf
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/arti...0/?tool=pubmed
A catalytically silent FAAH-1 variant drives anandamide transport in neurons. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245783/
The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans (full – 2011) http://www.lipidworld.com/content/10/1/129
Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. (full – 2011) http://www.jbc.org/content/early/201...10.202853.long
Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21740924
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/arti...0/?tool=pubmed
A role for the ventral hippocampal endocannabinoid system in fear-conditioned analgesia and fear responding in the presence of nociceptive tone in rats. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21864979
Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier (full – 2012) http://onlinelibrary.wiley.com/doi/1...2.02098.x/full
A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity (full – 2012) http://link.springer.com/article/10..../fulltext.html
The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action (full – 2012) http://www.biomedcentral.com/1471-2407/12/92
Endocannabinoid signaling in female reproduction. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382454/
The endocannabinoid system: an overview (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303140/
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372737/
Changes of Blood Endocannabinoids during Anaesthesia: a Special Case for Fatty Acid Amide Hydrolase Inhibition by Propofol? (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394128/
The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423256/
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525790/
β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptors (full – 2012) http://onlinelibrary.wiley.com/doi/1...12.01889.x/pdf
Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes. (full – 2012) http://press.endocrine.org/doi/full/...0/jc.2012-1780
Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449266/
Endocannabinoids at the synapse a decade after the Dies Mirabilis (29 March 2001): what we still do not know. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424745/
Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase - Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480564/
The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB1 and FAAH-independent mechanisms (full – 2012) http://onlinelibrary.wiley.com/doi/1...2.02208.x/full
Acute reduction of anandamide-hydrolase (FAAH) activity is coupled with a reduction of nociceptive pathways facilitation in medication-overuse headache subjects after withdrawal treatment. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/2...?dopt=Abstract
Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes (abst – 2012) http://jop.sagepub.com/content/26/10/1391
Spinal Cord Fatty Acid Amide Hydrolase (FAAH) in Normal Micturition Control and Bladder Overactivity in Awake Rats. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/23219540
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22627170
Inhibition of FAAH and activation of PPAR: New approaches to the treatment of cognitive dysfunction and drug addiction. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662489/
Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854987/
Elevated Anandamide and Related N-Acylethanolamine Levels Occur in the Peripheral Blood of Women With Ectopic Pregnancy and Are Mirrored by Changes in Peripheral Fatty Acid Amide Hydrolase Activity. (full – 2013) http://press.endocrine.org/doi/full/...0/jc.2012-3390
Parsing the players: 2-AG synthesis and degradation in the CNS (full – 2013) http://onlinelibrary.wiley.com/doi/1...bph.12411/full
Cannabinoid signaling and liver therapeutics. (full – 2013) http://www.journal-of-hepatology.eu/...212-2/fulltext
Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788575/
Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21930339
Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism (full – 2013) http://www.plosone.org/article/info%...l.pone.0060040
Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Anti-Withdrawal Effects in Morphine-Dependent Mice. (full – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23303065
Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice. (full – 2013) http://atvb.ahajournals.org/content/33/2/215.long
Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24445122
FAAH selectively influences placebo effects. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24042479
The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23743650
Long-term consequences of perinatal fatty acid amino hydrolase inhibition (abst – 2013) http://onlinelibrary.wiley.com/doi/1...12500/abstract
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24384256
Impulsivity, Variation in the Cannabinoid Receptor (CNR1) and Fatty Acid Amide Hydrolase (FAAH) Genes, and Marijuana-Related Problems. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24172113
Decreased Enteric Fatty Acid Amide Hydrolase Activity is Associated with Colonic Inertia in Slow Transit Constipation (abst – 2013) http://onlinelibrary.wiley.com/doi/1...12346/abstract
Inhibition of fatty acid amide hydrolase (FAAH) as a novel therapeutic strategy in the treatment of pain and inflammatory diseases in the gastrointestinal tract (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24275607
Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23806692
Amygdala FAAH and anandamide: mediating protection and recovery from stress. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24325918
Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23122699
(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23455058
Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries. (full – 2014) http://download.springer.com/static/...74992&ext=.pdf
Getting high on the endocannabinoid system. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997295/
Inhibition of Fatty Acid binding proteins elevates brain anandamide levels and produces analgesia. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976407/
FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway (full – 2014) http://www.impactjournals.com/oncota...e&op=view&path[]=1723&path[]=2142
Prolonged monoacylglycerol lipase blockade causes equivalent CB1-receptor mediated adaptations in FAAH wild type and knockout mice. (full – 2014) http://jpet.aspetjournals.org/conten...14.212753.long
Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation (full – 2014) http://www.nature.com/tp/journal/v4/...tp201453a.html
Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus. (full – 2014) http://journal.frontiersin.org/Journ...014.00056/full
The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease? (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025825/
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective. (full– 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Association of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population (full – 2014) http://onlinelibrary.wiley.com/doi/10.1002/mgg3.69/full
Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study. (full– 2014) http://www.plosone.org/article/info%...l.pone.0103479
The expression of cannabinoid receptor 1 is significantly increased in atopic patients (full – 2014) http://www.jacionline.org/article/S0...936-9/fulltext
Ketoconazole Inhibits the Cellular Uptake of Anandamide via Inhibition of FAAH at Pharmacologically Relevant Concentrations (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900727/
Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788575/
The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995979/
Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects. (full – 2014) http://onlinelibrary.wiley.com/doi/1...oby.20728/full
Cannabinoids as therapeutic agents in cancer: current status and future implications. (link to PDF- 2014) http://www.impactjournals.com/oncota...e&op=view&path[]=2233
Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24460851
No more pain upon Gq -protein-coupled receptor activation: role of endocannabinoids. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24494686
Anandamide in primary sensory neurons: too much of a good thing? (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24494681
Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s). (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24361246
Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24508383
Switching cannabinoid response from CB2 agonists to FAAH inhibitors. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24508127
Targeting the cannabinoid system for pain relief? (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24529672
1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24513048
Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain depressed behavior in rats. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24583930
Endocannabinoid-Hydrolysing Enzymes in the Post-Mortem Cerebellum of Humans Affected by Hereditary Autosomal Dominant Ataxias. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24642775
Toward modulation of the endocannabinoid system for treatment of gastrointestinal disease: FAAHster but not "higher". (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24641009
Elevation of Endogenous Anandamide Impairs LTP, Learning and Memory through CB1 Receptor Signaling in Mice. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24648181
Anticonvulsant Effects of N-Arachidonoyl-Serotonin, a Dual FAAH Enzyme and TRPV1 Channel Blocker, on Experimental Seizures: The Roles of Cannabinoid CB1 Receptors and TRPV1 Channels. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24674273
Inhibition of Peripheral Fatty Acid Amide Hydrolase Depresses Activities of Bladder Mechanosensitive Nerve Fibers of the Rat. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24746881
New players in the fatty acyl ethanolamide metabolism. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24747663
Endocannabinoid Regulation in Human Endometrium Across the Menstrual Cycle (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24819878
Endocannabinoid signaling in Alzheimer’s disease: current knowledge and future directions. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24813316
Functionalization of β-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24831513
Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24858366
The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24861565
The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24911644
Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24915981
PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Non-Human Primates. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25004399
The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects (abst – 2014) http://onlinelibrary.wiley.com/doi/1...12160/abstract
Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species (abst – 2014) http://onlinelibrary.wiley.com/doi/1...23727/abstract
Endocannabinoid modulation by FAAH and MAGL within the analgesic circuitry of the periaqueductal grey. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25041240
Inhibition of FAAH enzyme by pterostilbene: potential mechanism of anxiolytic action (abst – 2014) http://www.fasebj.org/content/28/1_S...6-4103f0c84daf
The FAAH inhibitor PF-04457845 has THC-like rewarding and reinstatement effects in squirrel monkeys and increases dopamine levels in the nucleus accumbens shell in rats (abst – 2014) http://www.fasebj.org/content/28/1_S...6-4103f0c84daf
Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid Amide Hydrolase Activity (abst – 2014) http://www.jbc.org/content/289/13/93...3-49611e578de4
Endocannabinoid-hydrolysing enzymes in the post-mortem cerebellum of humans affected by hereditary autosomal dominant ataxias. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24642775
Endocannabinoid Regulation in Human Endometrium Across the Menstrual Cycle (abst – 2014) http://rsx.sagepub.com/content/early...33730.abstract
Fenitrothion action at the endocannabinoid system leading to spermatotoxicity in Wistar rats. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24998969
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/arti...0/?tool=pubmed
A catalytically silent FAAH-1 variant drives anandamide transport in neurons. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245783/
The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans (full – 2011) http://www.lipidworld.com/content/10/1/129
Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. (full – 2011) http://www.jbc.org/content/early/201...10.202853.long
Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21740924
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/arti...0/?tool=pubmed
A role for the ventral hippocampal endocannabinoid system in fear-conditioned analgesia and fear responding in the presence of nociceptive tone in rats. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21864979
Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier (full – 2012) http://onlinelibrary.wiley.com/doi/1...2.02098.x/full
A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity (full – 2012) http://link.springer.com/article/10..../fulltext.html
The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action (full – 2012) http://www.biomedcentral.com/1471-2407/12/92
Endocannabinoid signaling in female reproduction. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382454/
The endocannabinoid system: an overview (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303140/
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372737/
Changes of Blood Endocannabinoids during Anaesthesia: a Special Case for Fatty Acid Amide Hydrolase Inhibition by Propofol? (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394128/
The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423256/
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525790/
β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptors (full – 2012) http://onlinelibrary.wiley.com/doi/1...12.01889.x/pdf
Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes. (full – 2012) http://press.endocrine.org/doi/full/...0/jc.2012-1780
Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449266/
Endocannabinoids at the synapse a decade after the Dies Mirabilis (29 March 2001): what we still do not know. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424745/
Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase - Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology. (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480564/
The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB1 and FAAH-independent mechanisms (full – 2012) http://onlinelibrary.wiley.com/doi/1...2.02208.x/full
Acute reduction of anandamide-hydrolase (FAAH) activity is coupled with a reduction of nociceptive pathways facilitation in medication-overuse headache subjects after withdrawal treatment. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/2...?dopt=Abstract
Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes (abst – 2012) http://jop.sagepub.com/content/26/10/1391
Spinal Cord Fatty Acid Amide Hydrolase (FAAH) in Normal Micturition Control and Bladder Overactivity in Awake Rats. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/23219540
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/22627170
Inhibition of FAAH and activation of PPAR: New approaches to the treatment of cognitive dysfunction and drug addiction. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662489/
Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854987/
Elevated Anandamide and Related N-Acylethanolamine Levels Occur in the Peripheral Blood of Women With Ectopic Pregnancy and Are Mirrored by Changes in Peripheral Fatty Acid Amide Hydrolase Activity. (full – 2013) http://press.endocrine.org/doi/full/...0/jc.2012-3390
Parsing the players: 2-AG synthesis and degradation in the CNS (full – 2013) http://onlinelibrary.wiley.com/doi/1...bph.12411/full
Cannabinoid signaling and liver therapeutics. (full – 2013) http://www.journal-of-hepatology.eu/...212-2/fulltext
Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788575/
Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/21930339
Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism (full – 2013) http://www.plosone.org/article/info%...l.pone.0060040
Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Anti-Withdrawal Effects in Morphine-Dependent Mice. (full – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23303065
Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice. (full – 2013) http://atvb.ahajournals.org/content/33/2/215.long
Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24445122
FAAH selectively influences placebo effects. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24042479
The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23743650
Long-term consequences of perinatal fatty acid amino hydrolase inhibition (abst – 2013) http://onlinelibrary.wiley.com/doi/1...12500/abstract
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24384256
Impulsivity, Variation in the Cannabinoid Receptor (CNR1) and Fatty Acid Amide Hydrolase (FAAH) Genes, and Marijuana-Related Problems. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24172113
Decreased Enteric Fatty Acid Amide Hydrolase Activity is Associated with Colonic Inertia in Slow Transit Constipation (abst – 2013) http://onlinelibrary.wiley.com/doi/1...12346/abstract
Inhibition of fatty acid amide hydrolase (FAAH) as a novel therapeutic strategy in the treatment of pain and inflammatory diseases in the gastrointestinal tract (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24275607
Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23806692
Amygdala FAAH and anandamide: mediating protection and recovery from stress. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/24325918
Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23122699
(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23455058
Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries. (full – 2014) http://download.springer.com/static/...74992&ext=.pdf
Getting high on the endocannabinoid system. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997295/
Inhibition of Fatty Acid binding proteins elevates brain anandamide levels and produces analgesia. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976407/
FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway (full – 2014) http://www.impactjournals.com/oncota...e&op=view&path[]=1723&path[]=2142
Prolonged monoacylglycerol lipase blockade causes equivalent CB1-receptor mediated adaptations in FAAH wild type and knockout mice. (full – 2014) http://jpet.aspetjournals.org/conten...14.212753.long
Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation (full – 2014) http://www.nature.com/tp/journal/v4/...tp201453a.html
Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus. (full – 2014) http://journal.frontiersin.org/Journ...014.00056/full
The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease? (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025825/
2012 Division of Medicinal Chemistry Award Address: Trekking the Cannabinoid Road: A Personal Perspective. (full– 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064474/
Association of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population (full – 2014) http://onlinelibrary.wiley.com/doi/10.1002/mgg3.69/full
Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study. (full– 2014) http://www.plosone.org/article/info%...l.pone.0103479
The expression of cannabinoid receptor 1 is significantly increased in atopic patients (full – 2014) http://www.jacionline.org/article/S0...936-9/fulltext
Ketoconazole Inhibits the Cellular Uptake of Anandamide via Inhibition of FAAH at Pharmacologically Relevant Concentrations (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900727/
Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. (full – 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788575/
The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995979/
Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects. (full – 2014) http://onlinelibrary.wiley.com/doi/1...oby.20728/full
Cannabinoids as therapeutic agents in cancer: current status and future implications. (link to PDF- 2014) http://www.impactjournals.com/oncota...e&op=view&path[]=2233
Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24460851
No more pain upon Gq -protein-coupled receptor activation: role of endocannabinoids. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24494686
Anandamide in primary sensory neurons: too much of a good thing? (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24494681
Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s). (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24361246
Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24508383
Switching cannabinoid response from CB2 agonists to FAAH inhibitors. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24508127
Targeting the cannabinoid system for pain relief? (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24529672
1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24513048
Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain depressed behavior in rats. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24583930
Endocannabinoid-Hydrolysing Enzymes in the Post-Mortem Cerebellum of Humans Affected by Hereditary Autosomal Dominant Ataxias. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24642775
Toward modulation of the endocannabinoid system for treatment of gastrointestinal disease: FAAHster but not "higher". (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24641009
Elevation of Endogenous Anandamide Impairs LTP, Learning and Memory through CB1 Receptor Signaling in Mice. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24648181
Anticonvulsant Effects of N-Arachidonoyl-Serotonin, a Dual FAAH Enzyme and TRPV1 Channel Blocker, on Experimental Seizures: The Roles of Cannabinoid CB1 Receptors and TRPV1 Channels. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24674273
Inhibition of Peripheral Fatty Acid Amide Hydrolase Depresses Activities of Bladder Mechanosensitive Nerve Fibers of the Rat. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24746881
New players in the fatty acyl ethanolamide metabolism. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24747663
Endocannabinoid Regulation in Human Endometrium Across the Menstrual Cycle (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24819878
Endocannabinoid signaling in Alzheimer’s disease: current knowledge and future directions. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24813316
Functionalization of β-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24831513
Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24858366
The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24861565
The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24911644
Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24915981
PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Non-Human Primates. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25004399
The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects (abst – 2014) http://onlinelibrary.wiley.com/doi/1...12160/abstract
Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species (abst – 2014) http://onlinelibrary.wiley.com/doi/1...23727/abstract
Endocannabinoid modulation by FAAH and MAGL within the analgesic circuitry of the periaqueductal grey. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/25041240
Inhibition of FAAH enzyme by pterostilbene: potential mechanism of anxiolytic action (abst – 2014) http://www.fasebj.org/content/28/1_S...6-4103f0c84daf
The FAAH inhibitor PF-04457845 has THC-like rewarding and reinstatement effects in squirrel monkeys and increases dopamine levels in the nucleus accumbens shell in rats (abst – 2014) http://www.fasebj.org/content/28/1_S...6-4103f0c84daf
Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid Amide Hydrolase Activity (abst – 2014) http://www.jbc.org/content/289/13/93...3-49611e578de4
Endocannabinoid-hydrolysing enzymes in the post-mortem cerebellum of humans affected by hereditary autosomal dominant ataxias. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24642775
Endocannabinoid Regulation in Human Endometrium Across the Menstrual Cycle (abst – 2014) http://rsx.sagepub.com/content/early...33730.abstract
Fenitrothion action at the endocannabinoid system leading to spermatotoxicity in Wistar rats. (abst – 2014) http://www.ncbi.nlm.nih.gov/pubmed/24998969