Cannabinoid Reduces Incidence Of Diabetes
http://www.norml.org/index.cfm?Group_ID=6909
Marijuana Compound May Help Stop Diabetic Retinopathy
http://www.sciencedaily.com/releases…0227184647.htm
Cannabidiol lowers incidence of diabetes in non-obese diabetic mice
http://safeaccess.ca/research/diabetes.htm
Anticoagulant Effects of a Cannabis Extract in an Obese Rat Model
http://www.level1diet.com/research/id/14687
Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol
http://ajp.amjpathol.org/cgi/content/full/168/1/235
The Cannabinergic System as a Target for Anti-inflammatory Therapies
http://www.ingentaconnect.com/conten…00013/art00008
Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes
http://www.unboundmedicine.com/medli…_diabetic_rats
Cannabidiol reduces the development of diabetes in an animal study
http://www.cannabis-med.org/english/…l.php?id=219#3
Getting Eye On Cannabinoids
http://www.thehempire.com/index.php/…n_cannabinoids
Marijuana compound could prevent eye damage in diabetics
http://www.thehempire.com/index.php/…e_in_diabetics
The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice
http://www.uccs.edu/~rmelamed/Evolut…e_disease.html
Cannabidiol arrests onset of autoimmune diabetes in NOD mice
http://safeaccess.ca/research/diabetes.htm
#Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
http://www.pubmedcentral.nih.gov/art…tool=pmcentrez Expression and function of cannabinoid receptors in mouse islets. (full – 2010) http/www.landesbioscience.com/journals/islets/LiISLETS2-5.pdf
Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain (full – 2010) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC2845559/?toolmcentrez
Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. (full - 2010) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3005548/?toolubmed
Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy (full – 2010) http/diabetes.diabetesjournals.org/content/59/4/1046.full?sid=0bc8e3fa-5275-4b19-8acc-4aec5dfac384
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. (full – 2010) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3003779/
Cannabinoid Receptors are Coupled to Stimulation of Insulin Secretion from Mouse MIN6 β-cells (full – 2010) http/www.karger.com/Article/Pdf/320527
Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients (full – 2010) http/www.lipidworld.com/content/9/1/43
Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways. (full – 2010) http/diabetes.diabetesjournals.org/content/59/11/2826.full.pdf+html
Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes. (full - 2010) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC2925907/?toolubmed
Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy (full - 2010) http/www.natap.org/2010/newsUpdates/marijuana.pdf
A one-year study to assess the safety and efficacy of the CB1R inverse agonist taranabant in overweight and obese patients with type 2 diabetes. (full – 2010) http/onlinelibrary.wiley.com/doi/10.1111/j.1463-1326.2009.01188.x/full
Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes? (full – 2010) http/www.jci.org/articles/view/44099?search[abstract_text]=&search[article_text]=cannabinoid&search[authors_text]=&search[fpage]=&search[title_text]=&search[volume]=
Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients. (full – 2010) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC2868848/?toolubmed
Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation. (full– 2010) http/www.wjgnet.com/1948-9358/full/v1/i1/12.htm
AMELIORATIVE POTENTIAL OF CANNABIS SATIVA EXTRACT ON DIABETES INDUCED NEUROPATHIC PAIN IN RATS (full – 2010) http/www.ijpsr.com/V1I11/11%20Vol%201,%20Issue%2011,%20IJPSR,%20Paper%206.p df
Polymorphisms in the endocannabinoid receptor 1 in relation to fat mass distribution (full – 2010) http/www.eje-online.org/content/163/3/407.full
Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age. (abst – 2010) http/www.ncbi.nlm.nih.gov/pubmed/20936991
Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice. (abst – 2010) http/www.ncbi.nlm.nih.gov/pubmed/20937249
AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes. (abst – 2010) http/www.ncbi.nlm.nih.gov/pubmed/20816753
Endocannabinoid (EC) Receptor, CB1, and EC Enzymes' Expression in Primary Adipocyte Cultures of Lean and Obese Pre-pubertal Children in Relation to Adiponectin and Insulin (abst – 2010) http/www.degruyter.com/abstract/j/jpem.2010.23.issue-10/jpem.2010.162/jpem.2010.162.xml?rskey=38kdx0&result=22&q=cannabinoid
G1359A polymorphism in the cannabinoid receptor-1 gene is associated with metabolic syndrome in the Chinese Han population. (abst – 2010) http/www.ncbi.nlm.nih.gov/pubmed/20851297
GPR119 agonists for the potential treatment of type 2 diabetes and related metabolic disorders. (abst – 2010) http/www.ncbi.nlm.nih.gov/pubmed/21094910
Pot Compound Mitigates Diabetic Cardiomyopathy (news – 2010) http/www.norml.org/index.cfm?Group_ID=8424
Cannabinoids inhibit and may prevent neuropathic pain in diabetes. (news – 2010) http/medigardens.blogspot.com/2010/04/march-2010-cannabinoids-inhibit-and-may.html
Lab Notes: Pot Has Benefits for Diabetic Hearts (news – 2010) http/www.medpagetoday.com/LabNotes/LabNotes/23853
Light Marijuana Use Appears Protective Against Diabetes (news – 2010) http/www.clinicalpsychiatrynews.com/index.php?id=2407&cHash=071010&tx_ttnews[tt_news]=41212
Marijuana Smoking Associated with 66% Decrease in Diabetes Risk (news – 2010) http/www.internalmedicinenews.com/index.php?id=495&cHash=071010&tx_ttnews[tt_news]=18557
A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans. (full – 2011) http/joe.endocrinology-journals.org/content/211/2/177.long
Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy. (full – 2011) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3161308/
Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice (full– 2011) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3082575/?toolubmed
Hepatic n-3 Polyunsaturated Fatty Acid Depletion Promotes Steatosis and Insulin Resistance in Mice: Genomic Analysis of Cellular Targets (full – 2011) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3154437/
Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease. (full – 2011) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3686489/
Role for cannabinoid receptors in human proximal tubular hypertrophy. (full– 2011) http/content.karger.com/produktedb/produkte.asp?DOI=000323997&typdf
The association of the rs1049353 polymorphism of the CNR1 gene with hypoadiponectinemia. (full – 2011) http/www.rjme.ro/RJME/resources/files/520311791795.pdf
Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. (full – 2011) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3085542/
GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms (full – 2011) http/endo.endojournals.org/content/152/2/374.full?sid=c7413b30-1046-4f9c-b028-c46f78f293d9
Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis (full – 2011) http/diabetes.diabetesjournals.org/content/60/4/1055.full
Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells (full – 2011) http/diabetes.diabetesjournals.org/content/60/4/1198.full
TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats. (full – 2011) http/jpet.aspetjournals.org/content/339/1/228.long
Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice. (abst – 2011) http/www.ncbi.nlm.nih.gov/pubmed/21340622
Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans. (abst – 2011) http/www.unboundmedicine.com/medline/ebm/record/21564460/abstract/Cannabinoid_receptor_agonists_and_antagonists_stim ulate_insulin_secretion_from_isolated_human_islets _of_Langerhans_
Endocannabinoid signaling and energy metabolism: a target for dietary intervention. (abst – 2011) http/www.ncbi.nlm.nih.gov/pubmed/21470818
Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes. (abst – 2011) http/www.unboundmedicine.com/medline/ebm/record/21484568/abstract/Cannabinoids_and_Endocannabinoids_in_Metabolic_Dis orders_with_Focus_on_Diabetes_
Win 55,212-2 reduces cardiac ischaemia-reperfusion injury in zucker diabetic fatty rats:role of cb2 receptors and cardiac inos/enos expression. (abst – 2011) http/www.unboundmedicine.com/medline/ebm/record/21309057/abstract/Win_55212_2_reduces_cardiac_ischaemia_reperfusion_ injury_in_zucker_diabetic_fatty_rats:_role_of_cb2_ receptors_and_cardiac_inos/enos_expression_
Cannabidiol Dampens Streptozotocin-Induced Retinal Inflammation by Targeting of Microglial Activation (abst – 2011) http/abstracts.iovs.org/cgi/content/abstract/52/6/1002?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT
A Summary of Endocannabinoids and Obesity (news – 2011) http/evolutionarypsychiatry.blogspot.com/2011/04/summary-of-endocannabinoids-and-obesity.html
Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III. (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3289985/
The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3423238/
The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity. (full – 2012) http/diabetes.diabetesjournals.org/content/61/2/281.long
Endocannabinoids measurement in human saliva as potential biomarker of obesity. (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3409167/?toolubmed
Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3500919/
Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3493609/
Excess of the endocannabinoid anandamide during lactation induces overweight, fat accumulation and insulin resistance in adult mice (full – 2012) http/www.dmsjournal.com/content/4/1/35
Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant (full – 2012) http/www.nutritionj.com/content/11/1/50
Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3372498/
Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3484111/
Gut microbiota and the development of obesity. (full – 2012) http/scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112012000500007&lng=en&nrm=iso&tlng=en
The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models (full – 2012) http/jpet.aspetjournals.org/content/342/1/188.full.pdf+html
The Endocannabinoid System: Plant-Derived Cannabinoids in Diabetes and Diabetic Complications (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3349875/
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. (full - 2012) http/www.pnas.org/content/109/37/14966.long
Stimulating beta cell replication and improving islet graft function by GPR119 agonists (full – 2012) http/onlinelibrary.wiley.com/doi/10.1111/j.1432-2277.2011.01332.x/full
Islet protection and amelioration of diabetes type 2 in Psammomys obesus by treatment with cannabidiol (link to PDF - 2012) http/www.scirp.org/searchResult/Index.aspx?searchCode=Islet+protection+and+amelior ation+of+diabetes+type+2+in+Psammomys+obesus+by+tr eatment+with+cannabidiol
Characterization of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22609797
Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22487302
Induction of Glucose Intolerance by Acute Administration of Rimonabant. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22678147
TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22374408
A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design (S38.003) (abst – 2012) http/www.neurology.org/cgi/content/meeting_abstract/78/1_MeetingAbstracts/S38.003?maxtoshow=&hits=25&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=180&sortspec=date&resourcetype=HWCIT
G1359A polymorphism in the cannabinoid receptor-1 gene is associated with the presence of coronary artery disease in patients with type 2 diabetes (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22138970
A Multiple-Ascending-Dose Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Novel GPR40 Agonist, TAK-875, in Subjects With Type 2 Diabetes (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22669289
Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22490067
An enriched-enrolment, randomized withdrawal, flexible-dose, double-blind, placebocontrolled, parallel assignment efficacy study of nabilone as adjuvant in the treatment of diabetic peripheral neuropathic pain (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22921260
The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22943701
Reports of the death of CB1 antagonists have been greatly exaggerated: recent preclinical findings predict improved safety in the treatment of obesity. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22743603
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22959964
New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22674489
Study: Cannabis Use Associated With Decreased Prevailence Of Diabetes (news – 2012) http/norml.org/news/2012/12/20/study-cannabis-use-associated-with-decreased-prevalence-of-diabetes
Synthetic cannabinoid could treat pain in diabetes patients (news – 2012) http/www.medwirenews.com/57/102248/Diabetes/Synthetic_cannabinoid_could_treat_pain_in_diabetes _patients_.html
Study: Synthetic THC Analogue Mitigates Diabetic Neuropathy, Is ‘Well Tolerated’ In Patients (news – 2012) http/norml.org/news/2012/09/20/study-synthetic-thc-analogue-mitigates-diabetic-neuropathy-is-welltolerated-in-patients
Encouraging anti-diabetic results for new cannabinoid drug (news – 2012) http/www.diabetes.co.uk/news/2012/Dec/encouraging-anti-diabetic-results-for-new-cannabinoid-drug-99996010.html
New drug offers novel pain management therapy for diabetics. (news - 2012) http/www.thefreelibrary.com/New+drug+offers+novel+pain+management+therapy+for+ diabetics.-a0306899453
Drug offers new pain management therapy for diabetics (news – 2012) http/medicalxpress.com/news/2012-10-drug-pain-therapy-diabetics.html
The impact of marijuana use on glucose, insulin, and insulin resistance among US adults (full – 2013) http/www.amjmed.com/article/S0002-9343%2813%2900200-3/fulltext
Developmental Role for Endocannabinoid Signaling in Regulating Glucose Metabolism and Growth. (full – 2013) http/diabetes.diabetesjournals.org/content/62/7/2359.full?sid=2f5bda2b-a9c7-432a-9588-80c99189164d
Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function. (full – 2013) http/www.clinsci.org/cs/124/0467/1240467.pdf
Influence of G1359A polimorphysm of the cannabinoid receptor gene (CNR1) on insulin resistance and adipokines in patients with non alcoholic fatty liver disease. (full – 2013) http/scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112012000500039&lng=en&nrm=iso&tlng=en
The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3671751/
Modulating the endocannabinoid system in human health and disease: successes and failures (full – 2013) http/onlinelibrary.wiley.com/doi/10.1111/febs.12260/pdf
Reduced Food Intake is the Major Contributor to the Protective Effect of Rimonabant on Islet in Established Obesity-Associated Type 2 Diabetes. (full – 2013) http/www.eymj.org/DOIx.php?id=10.3349/ymj.2013.54.5.1127
Circulating endocannabinoids in insulin sensitive vs. Insulin resistant obese postmenopausal women. A MONET group study. (full – 2013) http/onlinelibrary.wiley.com/doi/10.1002/oby.20498/full
Insulin induces long-term depression of VTA dopamine neurons via endocannabinoids (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC4072656/
Is the cardiovascular system a therapeutic target for cannabidiol? (full – 2013) http/onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04351.x/full
The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome. (full – 2013) http/www.cell.com/cell-reports/fulltext/S2211-1247%2813%2900507-X
Cannabinoid Receptor 2 Expression in Human Proximal Tubule Cells is Regulated by Albumin Independent of ERK1/2 Signaling. (full – 2013) http/www.karger.com/Article/Pdf/354529
A potential role for GPR55 in gastrointestinal functions. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3660623/
A Novel Antidiabetic Drug, Fasiglifam/TAK-875, Acts as an Ago-Allosteric Modulator of FFAR1 (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3794927/
Randomized, double-blind, dose-ranging study of TAK-875, a novel GPR40 agonist, in Japanese patients with inadequately controlled type 2 diabetes. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3554318/
Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects With Type 2 Diabetes Mellitus. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3600727/
Activation of GPR40 as a therapeutic target for the treatment of type 2 diabetes. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3920793/
The complex effects of cannabinoids on insulin secretion from rat isolated islets of Langerhans. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23499687
TAK-875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β-cell dysfunction in Zucker diabetic fatty rats. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23848179
Effects of CB1 receptor blockade on monosodium glutamate induced hypometabolic and hypothalamic obesity in rats. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23620336
Synergetic Insulin Sensitizing Effect of Rimonabant and BGP-15 in Zucker-Obes Rats. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23640247
Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23747418
Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23839870
Activation of spinal cannabinoid cb2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23892011
Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23992544
Common polymorphism in the cannabinoid type 1 receptor gene (CNR1) is associated with microvascular complications in type 2 diabetes. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24075694
Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24120371
Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3839776/
Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23845579
Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23901038
Islet cannabinoid receptors: cellular distribution and biological function. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24005231
Role of Genetic Variation in the Cannabinoid Receptor Gene (CNR1) (G1359A Polymorphism) on Weight Loss and Cardiovascular Risk Factors After Liraglutide Treatment in Obese Patients With Diabetes Mellitus Type 2. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24322329
Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24445122
Fasiglifam as a new potential treatment option for patients with type 2 diabetes. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24195772
Marijuana: The next diabetes drug? (news – 2013) http/www.cnn.com/2013/05/23/health/time-marijuana-diabetes/index.html
Regular Marijuana Use is Associated With Favorable Indices to Diabetic Control, Say Investigators (news – 2013) http/www.news-medical.net/news/20130515/Regular-marijuana-use-is-associated-with-favorableindices-related-to-diabetic-control-say-investigators.aspx
Marijuana Users Have Better Blood Sugar Control (news – 2013) http/www.sciencedaily.com/releases/2013/05/130515085208.htm
Study: Why Pot Smokers Are Skinnier (news – 2013) http/www.theatlantic.com/health/archive/2013/05/study-why-pot-smokers-are-skinnier/275846/
Cannabis linked to prevention of diabetes (news – 2013) http/www.independent.co.uk/life-style/health-and-families/health-news/cannabis-linked-to-prevention-ofdiabetes-8616314.html
Marijuana Extract Holds Promise as Diabetes Treatment (news – 2013) http/www.newsmax.com/Health-News/Type-2-diabetes-diabetes-drugs-marijuana-experimental-drug-GWP42004/2013/07/19/id/516015
Study: Marijuana Smokers Are Thinner And Healthier Than Non-Users (news – 2013) http/www.opposingviews.com/i/society/study-marijuana-smokers-are-thinner-and-healthier-non-users
Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts. (full – 2014) http/journal.frontiersin.org/Journal/10.3389/fphys.2014.00100/full
Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice. (full – 2014) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3895006/
Vascular targets for cannabinoids: animal and human studies. (full – 2014) http/onlinelibrary.wiley.com/doi/10.1111/bph.12560/full
The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes. (full – 2014) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3995979/
A new face of endocannabinoids in pharmacotherapy. Part II. Role of endocannabinoids in inflammation-derived cardiovascular diseases. (full – 2014) http/www.jpp.krakow.pl/journal/archive/04_14/pdf/183_04_14_article.pdf
A Role for Trans-caryophyllene in the Moderation of Insulin Secretion. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24486541
Glucose metabolism: Focus on gut microbiota, the endocannabinoid system and beyond. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24631413
Mitochondria: A Possible Nexus for the Regulation of Energy Homeostasis by the Endocannabinoid System? (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24801388
Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24827776
GPR55: From orphan to metabolic regulator? (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24972076
Common polymorphism in the cannabinoid type 1 receptor gene (CNR1) is associated with microvascular complications in type 2 diabetes. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24075694
Physiology and therapeutics of the free fatty acid receptor GPR40. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24373235
Optimization of GPR40 Agonists for Type 2 Diabetes. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24900872
G-protein coupled receptor 40 agonists as novel therapeutics for type 2 diabetes. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24234912
Marijuana may help blood sugar control, study says (news – 2014) http/www.philly.com/philly/health/diabetes/Marijuana_may_help_blood_sugar_control_study_says. html
GPR40 agonists for the treatment of type 2 diabetes: life after "TAKing" a hit (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25604916
Marijuana Could Be the Answer to Fighting These 3 Diseases (news – 2015) (may require free registration) http://www.fool.com/investing/genera...g-these-3.aspx
New study links marijuana use and low body weight among Nunavik Inuit (news – 2015) http://www.nunatsiaqonline.ca/storie...ht_among_inuit
http://www.norml.org/index.cfm?Group_ID=6909
Marijuana Compound May Help Stop Diabetic Retinopathy
http://www.sciencedaily.com/releases…0227184647.htm
Cannabidiol lowers incidence of diabetes in non-obese diabetic mice
http://safeaccess.ca/research/diabetes.htm
Anticoagulant Effects of a Cannabis Extract in an Obese Rat Model
http://www.level1diet.com/research/id/14687
Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol
http://ajp.amjpathol.org/cgi/content/full/168/1/235
The Cannabinergic System as a Target for Anti-inflammatory Therapies
http://www.ingentaconnect.com/conten…00013/art00008
Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes
http://www.unboundmedicine.com/medli…_diabetic_rats
Cannabidiol reduces the development of diabetes in an animal study
http://www.cannabis-med.org/english/…l.php?id=219#3
Getting Eye On Cannabinoids
http://www.thehempire.com/index.php/…n_cannabinoids
Marijuana compound could prevent eye damage in diabetics
http://www.thehempire.com/index.php/…e_in_diabetics
The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice
http://www.uccs.edu/~rmelamed/Evolut…e_disease.html
Cannabidiol arrests onset of autoimmune diabetes in NOD mice
http://safeaccess.ca/research/diabetes.htm
#Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
http://www.pubmedcentral.nih.gov/art…tool=pmcentrez Expression and function of cannabinoid receptors in mouse islets. (full – 2010) http/www.landesbioscience.com/journals/islets/LiISLETS2-5.pdf
Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain (full – 2010) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC2845559/?toolmcentrez
Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. (full - 2010) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3005548/?toolubmed
Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy (full – 2010) http/diabetes.diabetesjournals.org/content/59/4/1046.full?sid=0bc8e3fa-5275-4b19-8acc-4aec5dfac384
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. (full – 2010) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3003779/
Cannabinoid Receptors are Coupled to Stimulation of Insulin Secretion from Mouse MIN6 β-cells (full – 2010) http/www.karger.com/Article/Pdf/320527
Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients (full – 2010) http/www.lipidworld.com/content/9/1/43
Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways. (full – 2010) http/diabetes.diabetesjournals.org/content/59/11/2826.full.pdf+html
Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes. (full - 2010) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC2925907/?toolubmed
Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy (full - 2010) http/www.natap.org/2010/newsUpdates/marijuana.pdf
A one-year study to assess the safety and efficacy of the CB1R inverse agonist taranabant in overweight and obese patients with type 2 diabetes. (full – 2010) http/onlinelibrary.wiley.com/doi/10.1111/j.1463-1326.2009.01188.x/full
Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes? (full – 2010) http/www.jci.org/articles/view/44099?search[abstract_text]=&search[article_text]=cannabinoid&search[authors_text]=&search[fpage]=&search[title_text]=&search[volume]=
Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients. (full – 2010) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC2868848/?toolubmed
Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation. (full– 2010) http/www.wjgnet.com/1948-9358/full/v1/i1/12.htm
AMELIORATIVE POTENTIAL OF CANNABIS SATIVA EXTRACT ON DIABETES INDUCED NEUROPATHIC PAIN IN RATS (full – 2010) http/www.ijpsr.com/V1I11/11%20Vol%201,%20Issue%2011,%20IJPSR,%20Paper%206.p df
Polymorphisms in the endocannabinoid receptor 1 in relation to fat mass distribution (full – 2010) http/www.eje-online.org/content/163/3/407.full
Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age. (abst – 2010) http/www.ncbi.nlm.nih.gov/pubmed/20936991
Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice. (abst – 2010) http/www.ncbi.nlm.nih.gov/pubmed/20937249
AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes. (abst – 2010) http/www.ncbi.nlm.nih.gov/pubmed/20816753
Endocannabinoid (EC) Receptor, CB1, and EC Enzymes' Expression in Primary Adipocyte Cultures of Lean and Obese Pre-pubertal Children in Relation to Adiponectin and Insulin (abst – 2010) http/www.degruyter.com/abstract/j/jpem.2010.23.issue-10/jpem.2010.162/jpem.2010.162.xml?rskey=38kdx0&result=22&q=cannabinoid
G1359A polymorphism in the cannabinoid receptor-1 gene is associated with metabolic syndrome in the Chinese Han population. (abst – 2010) http/www.ncbi.nlm.nih.gov/pubmed/20851297
GPR119 agonists for the potential treatment of type 2 diabetes and related metabolic disorders. (abst – 2010) http/www.ncbi.nlm.nih.gov/pubmed/21094910
Pot Compound Mitigates Diabetic Cardiomyopathy (news – 2010) http/www.norml.org/index.cfm?Group_ID=8424
Cannabinoids inhibit and may prevent neuropathic pain in diabetes. (news – 2010) http/medigardens.blogspot.com/2010/04/march-2010-cannabinoids-inhibit-and-may.html
Lab Notes: Pot Has Benefits for Diabetic Hearts (news – 2010) http/www.medpagetoday.com/LabNotes/LabNotes/23853
Light Marijuana Use Appears Protective Against Diabetes (news – 2010) http/www.clinicalpsychiatrynews.com/index.php?id=2407&cHash=071010&tx_ttnews[tt_news]=41212
Marijuana Smoking Associated with 66% Decrease in Diabetes Risk (news – 2010) http/www.internalmedicinenews.com/index.php?id=495&cHash=071010&tx_ttnews[tt_news]=18557
A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans. (full – 2011) http/joe.endocrinology-journals.org/content/211/2/177.long
Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy. (full – 2011) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3161308/
Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice (full– 2011) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3082575/?toolubmed
Hepatic n-3 Polyunsaturated Fatty Acid Depletion Promotes Steatosis and Insulin Resistance in Mice: Genomic Analysis of Cellular Targets (full – 2011) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3154437/
Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease. (full – 2011) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3686489/
Role for cannabinoid receptors in human proximal tubular hypertrophy. (full– 2011) http/content.karger.com/produktedb/produkte.asp?DOI=000323997&typdf
The association of the rs1049353 polymorphism of the CNR1 gene with hypoadiponectinemia. (full – 2011) http/www.rjme.ro/RJME/resources/files/520311791795.pdf
Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. (full – 2011) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3085542/
GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms (full – 2011) http/endo.endojournals.org/content/152/2/374.full?sid=c7413b30-1046-4f9c-b028-c46f78f293d9
Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis (full – 2011) http/diabetes.diabetesjournals.org/content/60/4/1055.full
Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells (full – 2011) http/diabetes.diabetesjournals.org/content/60/4/1198.full
TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats. (full – 2011) http/jpet.aspetjournals.org/content/339/1/228.long
Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice. (abst – 2011) http/www.ncbi.nlm.nih.gov/pubmed/21340622
Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans. (abst – 2011) http/www.unboundmedicine.com/medline/ebm/record/21564460/abstract/Cannabinoid_receptor_agonists_and_antagonists_stim ulate_insulin_secretion_from_isolated_human_islets _of_Langerhans_
Endocannabinoid signaling and energy metabolism: a target for dietary intervention. (abst – 2011) http/www.ncbi.nlm.nih.gov/pubmed/21470818
Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes. (abst – 2011) http/www.unboundmedicine.com/medline/ebm/record/21484568/abstract/Cannabinoids_and_Endocannabinoids_in_Metabolic_Dis orders_with_Focus_on_Diabetes_
Win 55,212-2 reduces cardiac ischaemia-reperfusion injury in zucker diabetic fatty rats:role of cb2 receptors and cardiac inos/enos expression. (abst – 2011) http/www.unboundmedicine.com/medline/ebm/record/21309057/abstract/Win_55212_2_reduces_cardiac_ischaemia_reperfusion_ injury_in_zucker_diabetic_fatty_rats:_role_of_cb2_ receptors_and_cardiac_inos/enos_expression_
Cannabidiol Dampens Streptozotocin-Induced Retinal Inflammation by Targeting of Microglial Activation (abst – 2011) http/abstracts.iovs.org/cgi/content/abstract/52/6/1002?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT
A Summary of Endocannabinoids and Obesity (news – 2011) http/evolutionarypsychiatry.blogspot.com/2011/04/summary-of-endocannabinoids-and-obesity.html
Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III. (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3289985/
The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3423238/
The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity. (full – 2012) http/diabetes.diabetesjournals.org/content/61/2/281.long
Endocannabinoids measurement in human saliva as potential biomarker of obesity. (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3409167/?toolubmed
Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3500919/
Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3493609/
Excess of the endocannabinoid anandamide during lactation induces overweight, fat accumulation and insulin resistance in adult mice (full – 2012) http/www.dmsjournal.com/content/4/1/35
Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant (full – 2012) http/www.nutritionj.com/content/11/1/50
Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3372498/
Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3484111/
Gut microbiota and the development of obesity. (full – 2012) http/scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112012000500007&lng=en&nrm=iso&tlng=en
The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models (full – 2012) http/jpet.aspetjournals.org/content/342/1/188.full.pdf+html
The Endocannabinoid System: Plant-Derived Cannabinoids in Diabetes and Diabetic Complications (full – 2012) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3349875/
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. (full - 2012) http/www.pnas.org/content/109/37/14966.long
Stimulating beta cell replication and improving islet graft function by GPR119 agonists (full – 2012) http/onlinelibrary.wiley.com/doi/10.1111/j.1432-2277.2011.01332.x/full
Islet protection and amelioration of diabetes type 2 in Psammomys obesus by treatment with cannabidiol (link to PDF - 2012) http/www.scirp.org/searchResult/Index.aspx?searchCode=Islet+protection+and+amelior ation+of+diabetes+type+2+in+Psammomys+obesus+by+tr eatment+with+cannabidiol
Characterization of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22609797
Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22487302
Induction of Glucose Intolerance by Acute Administration of Rimonabant. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22678147
TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22374408
A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design (S38.003) (abst – 2012) http/www.neurology.org/cgi/content/meeting_abstract/78/1_MeetingAbstracts/S38.003?maxtoshow=&hits=25&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=180&sortspec=date&resourcetype=HWCIT
G1359A polymorphism in the cannabinoid receptor-1 gene is associated with the presence of coronary artery disease in patients with type 2 diabetes (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22138970
A Multiple-Ascending-Dose Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Novel GPR40 Agonist, TAK-875, in Subjects With Type 2 Diabetes (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22669289
Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22490067
An enriched-enrolment, randomized withdrawal, flexible-dose, double-blind, placebocontrolled, parallel assignment efficacy study of nabilone as adjuvant in the treatment of diabetic peripheral neuropathic pain (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22921260
The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22943701
Reports of the death of CB1 antagonists have been greatly exaggerated: recent preclinical findings predict improved safety in the treatment of obesity. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22743603
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22959964
New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance. (abst – 2012) http/www.ncbi.nlm.nih.gov/pubmed/22674489
Study: Cannabis Use Associated With Decreased Prevailence Of Diabetes (news – 2012) http/norml.org/news/2012/12/20/study-cannabis-use-associated-with-decreased-prevalence-of-diabetes
Synthetic cannabinoid could treat pain in diabetes patients (news – 2012) http/www.medwirenews.com/57/102248/Diabetes/Synthetic_cannabinoid_could_treat_pain_in_diabetes _patients_.html
Study: Synthetic THC Analogue Mitigates Diabetic Neuropathy, Is ‘Well Tolerated’ In Patients (news – 2012) http/norml.org/news/2012/09/20/study-synthetic-thc-analogue-mitigates-diabetic-neuropathy-is-welltolerated-in-patients
Encouraging anti-diabetic results for new cannabinoid drug (news – 2012) http/www.diabetes.co.uk/news/2012/Dec/encouraging-anti-diabetic-results-for-new-cannabinoid-drug-99996010.html
New drug offers novel pain management therapy for diabetics. (news - 2012) http/www.thefreelibrary.com/New+drug+offers+novel+pain+management+therapy+for+ diabetics.-a0306899453
Drug offers new pain management therapy for diabetics (news – 2012) http/medicalxpress.com/news/2012-10-drug-pain-therapy-diabetics.html
The impact of marijuana use on glucose, insulin, and insulin resistance among US adults (full – 2013) http/www.amjmed.com/article/S0002-9343%2813%2900200-3/fulltext
Developmental Role for Endocannabinoid Signaling in Regulating Glucose Metabolism and Growth. (full – 2013) http/diabetes.diabetesjournals.org/content/62/7/2359.full?sid=2f5bda2b-a9c7-432a-9588-80c99189164d
Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function. (full – 2013) http/www.clinsci.org/cs/124/0467/1240467.pdf
Influence of G1359A polimorphysm of the cannabinoid receptor gene (CNR1) on insulin resistance and adipokines in patients with non alcoholic fatty liver disease. (full – 2013) http/scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112012000500039&lng=en&nrm=iso&tlng=en
The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3671751/
Modulating the endocannabinoid system in human health and disease: successes and failures (full – 2013) http/onlinelibrary.wiley.com/doi/10.1111/febs.12260/pdf
Reduced Food Intake is the Major Contributor to the Protective Effect of Rimonabant on Islet in Established Obesity-Associated Type 2 Diabetes. (full – 2013) http/www.eymj.org/DOIx.php?id=10.3349/ymj.2013.54.5.1127
Circulating endocannabinoids in insulin sensitive vs. Insulin resistant obese postmenopausal women. A MONET group study. (full – 2013) http/onlinelibrary.wiley.com/doi/10.1002/oby.20498/full
Insulin induces long-term depression of VTA dopamine neurons via endocannabinoids (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC4072656/
Is the cardiovascular system a therapeutic target for cannabidiol? (full – 2013) http/onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04351.x/full
The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome. (full – 2013) http/www.cell.com/cell-reports/fulltext/S2211-1247%2813%2900507-X
Cannabinoid Receptor 2 Expression in Human Proximal Tubule Cells is Regulated by Albumin Independent of ERK1/2 Signaling. (full – 2013) http/www.karger.com/Article/Pdf/354529
A potential role for GPR55 in gastrointestinal functions. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3660623/
A Novel Antidiabetic Drug, Fasiglifam/TAK-875, Acts as an Ago-Allosteric Modulator of FFAR1 (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3794927/
Randomized, double-blind, dose-ranging study of TAK-875, a novel GPR40 agonist, in Japanese patients with inadequately controlled type 2 diabetes. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3554318/
Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects With Type 2 Diabetes Mellitus. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3600727/
Activation of GPR40 as a therapeutic target for the treatment of type 2 diabetes. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3920793/
The complex effects of cannabinoids on insulin secretion from rat isolated islets of Langerhans. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23499687
TAK-875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β-cell dysfunction in Zucker diabetic fatty rats. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23848179
Effects of CB1 receptor blockade on monosodium glutamate induced hypometabolic and hypothalamic obesity in rats. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23620336
Synergetic Insulin Sensitizing Effect of Rimonabant and BGP-15 in Zucker-Obes Rats. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23640247
Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23747418
Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23839870
Activation of spinal cannabinoid cb2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23892011
Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23992544
Common polymorphism in the cannabinoid type 1 receptor gene (CNR1) is associated with microvascular complications in type 2 diabetes. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24075694
Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24120371
Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase. (full – 2013) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3839776/
Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23845579
Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/23901038
Islet cannabinoid receptors: cellular distribution and biological function. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24005231
Role of Genetic Variation in the Cannabinoid Receptor Gene (CNR1) (G1359A Polymorphism) on Weight Loss and Cardiovascular Risk Factors After Liraglutide Treatment in Obese Patients With Diabetes Mellitus Type 2. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24322329
Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24445122
Fasiglifam as a new potential treatment option for patients with type 2 diabetes. (abst – 2013) http/www.ncbi.nlm.nih.gov/pubmed/24195772
Marijuana: The next diabetes drug? (news – 2013) http/www.cnn.com/2013/05/23/health/time-marijuana-diabetes/index.html
Regular Marijuana Use is Associated With Favorable Indices to Diabetic Control, Say Investigators (news – 2013) http/www.news-medical.net/news/20130515/Regular-marijuana-use-is-associated-with-favorableindices-related-to-diabetic-control-say-investigators.aspx
Marijuana Users Have Better Blood Sugar Control (news – 2013) http/www.sciencedaily.com/releases/2013/05/130515085208.htm
Study: Why Pot Smokers Are Skinnier (news – 2013) http/www.theatlantic.com/health/archive/2013/05/study-why-pot-smokers-are-skinnier/275846/
Cannabis linked to prevention of diabetes (news – 2013) http/www.independent.co.uk/life-style/health-and-families/health-news/cannabis-linked-to-prevention-ofdiabetes-8616314.html
Marijuana Extract Holds Promise as Diabetes Treatment (news – 2013) http/www.newsmax.com/Health-News/Type-2-diabetes-diabetes-drugs-marijuana-experimental-drug-GWP42004/2013/07/19/id/516015
Study: Marijuana Smokers Are Thinner And Healthier Than Non-Users (news – 2013) http/www.opposingviews.com/i/society/study-marijuana-smokers-are-thinner-and-healthier-non-users
Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts. (full – 2014) http/journal.frontiersin.org/Journal/10.3389/fphys.2014.00100/full
Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice. (full – 2014) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3895006/
Vascular targets for cannabinoids: animal and human studies. (full – 2014) http/onlinelibrary.wiley.com/doi/10.1111/bph.12560/full
The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes. (full – 2014) http/www.ncbi.nlm.nih.gov/pmc/articles/PMC3995979/
A new face of endocannabinoids in pharmacotherapy. Part II. Role of endocannabinoids in inflammation-derived cardiovascular diseases. (full – 2014) http/www.jpp.krakow.pl/journal/archive/04_14/pdf/183_04_14_article.pdf
A Role for Trans-caryophyllene in the Moderation of Insulin Secretion. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24486541
Glucose metabolism: Focus on gut microbiota, the endocannabinoid system and beyond. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24631413
Mitochondria: A Possible Nexus for the Regulation of Energy Homeostasis by the Endocannabinoid System? (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24801388
Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24827776
GPR55: From orphan to metabolic regulator? (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24972076
Common polymorphism in the cannabinoid type 1 receptor gene (CNR1) is associated with microvascular complications in type 2 diabetes. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24075694
Physiology and therapeutics of the free fatty acid receptor GPR40. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24373235
Optimization of GPR40 Agonists for Type 2 Diabetes. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24900872
G-protein coupled receptor 40 agonists as novel therapeutics for type 2 diabetes. (abst – 2014) http/www.ncbi.nlm.nih.gov/pubmed/24234912
Marijuana may help blood sugar control, study says (news – 2014) http/www.philly.com/philly/health/diabetes/Marijuana_may_help_blood_sugar_control_study_says. html
GPR40 agonists for the treatment of type 2 diabetes: life after "TAKing" a hit (abst – 2015) http://www.ncbi.nlm.nih.gov/pubmed/25604916
Marijuana Could Be the Answer to Fighting These 3 Diseases (news – 2015) (may require free registration) http://www.fool.com/investing/genera...g-these-3.aspx
New study links marijuana use and low body weight among Nunavik Inuit (news – 2015) http://www.nunatsiaqonline.ca/storie...ht_among_inuit