AM-111 (news – undated) http://www.aurismedical.com/p/therap..._111.php?lg=en
A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss (full – 2003) http://www.jneurosci.org/content/23/24/8596.long
Cochlear implantation trauma and noise-induced hearing loss: Apoptosis and therapeutic strategies (full - 2006)http://onlinelibrary.wiley.com/doi/1...ar.a.20305/pdf
AM-111 reduces hearing loss in a guinea pig model of acute labyrinthitis (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/18322422
Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study (abst – 2007)http://www.ncbi.nlm.nih.gov/pubmed/17712672
AM-111 protects against permanent hearing loss from impulse noise trauma (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/16839720
AM-111 prevents hearing loss from semicircular canal injury in otitis media (full – 2009)http://onlinelibrary.wiley.com/doi/1...lary.20759/pdf
Blocking pro-cell-death signal pathways to conserve hearing (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19923808
CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS Patent application number: 20100016218 (full – 2010) http://www.faqs.org/patents/app/20100016218
Otoprotective Effect of AM-111 Also Shown In Model of Cochlear Ischemia (news – 2010) http://www.biospace.com/news_story.aspx?StoryID=192710
JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21628793
Protection against ischemic cochlear damage by intratympanic administration of AM-111 (abst – 2011)http://www.ncbi.nlm.nih.gov/pubmed/22089955
The JNK inhibitor XG-102 protects against TNBS-induced colitis (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302790/
Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury (abst – 2012)http://www.ncbi.nlm.nih.gov/pubmed/22426389
Analysis: Drugmakers step up search for hearing loss medicines (news – 2012) http://www.reuters.com/article/2012/...8B102H20121202
Molecular mechanisms involved in cochlear implantation trauma and the protection of hearing and auditory sensory cells by inhibition of c-Jun-N-terminal kinase signaling (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23382052
Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model (abst – 2013)http://www.ncbi.nlm.nih.gov/pubmed/23501261
A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss (full – 2003) http://www.jneurosci.org/content/23/24/8596.long
Cochlear implantation trauma and noise-induced hearing loss: Apoptosis and therapeutic strategies (full - 2006)http://onlinelibrary.wiley.com/doi/1...ar.a.20305/pdf
AM-111 reduces hearing loss in a guinea pig model of acute labyrinthitis (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/18322422
Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study (abst – 2007)http://www.ncbi.nlm.nih.gov/pubmed/17712672
AM-111 protects against permanent hearing loss from impulse noise trauma (abst – 2007) http://www.ncbi.nlm.nih.gov/pubmed/16839720
AM-111 prevents hearing loss from semicircular canal injury in otitis media (full – 2009)http://onlinelibrary.wiley.com/doi/1...lary.20759/pdf
Blocking pro-cell-death signal pathways to conserve hearing (abst – 2009) http://www.ncbi.nlm.nih.gov/pubmed/19923808
CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS Patent application number: 20100016218 (full – 2010) http://www.faqs.org/patents/app/20100016218
Otoprotective Effect of AM-111 Also Shown In Model of Cochlear Ischemia (news – 2010) http://www.biospace.com/news_story.aspx?StoryID=192710
JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21628793
Protection against ischemic cochlear damage by intratympanic administration of AM-111 (abst – 2011)http://www.ncbi.nlm.nih.gov/pubmed/22089955
The JNK inhibitor XG-102 protects against TNBS-induced colitis (full – 2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302790/
Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury (abst – 2012)http://www.ncbi.nlm.nih.gov/pubmed/22426389
Analysis: Drugmakers step up search for hearing loss medicines (news – 2012) http://www.reuters.com/article/2012/...8B102H20121202
Molecular mechanisms involved in cochlear implantation trauma and the protection of hearing and auditory sensory cells by inhibition of c-Jun-N-terminal kinase signaling (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23382052
Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model (abst – 2013)http://www.ncbi.nlm.nih.gov/pubmed/23501261