URB-754: A new class of designer drug and 12 synthetic cannabinoids detected in illegal products (abst – 2012)http://www.ncbi.nlm.nih.gov/pubmed/23063179
Detection of urinary metabolites of AM-2201 and UR-144, two novel synthetic cannabinoids (abst – 2013)http://www.ncbi...
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UR-144
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TARANABANT / MK-0364
The discovery of taranabant, a selective cannabinoid-1 receptor inverse agonist for the treatment of obesity (full – 2008)http://onlinelibrary.wiley.com/doi/1....200700255/pdf
Taranabant, a novel cannabinoid type 1 receptor inverse agonist (abst – 2008) http://www.ncbi.nlm.nih.gov/pubme...
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TM-38837
Experimental obesity drug avoids brain effects that troubled predecessors (news – 2010) http://phys.org/news197905295.html Low brain CB1 receptor occupancy by a second...
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TAK- 875 / FASIGLIFAM
TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats (full – 2011)http://jpet.aspetjournals.org/content/339/1/228.long Takeda moves potential first-in-cl...
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SURINABANT / SR 147778
SR147778 [5-(4-Bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a New Potent and Selective Antagonist of the CB1 Cannabinoid Receptor: Biochemical and Pharmacological Characterization...
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SR-144528
p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells (full – 2005)http://www.sciencedirect.com/science...14579305010057
Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor (full – 2006)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1616976/ The CB2 cannabinoid receptor si...
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MAGL / MGL / MONOACYLGLYCEROL LIPASE > 2006-2014
Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16310817
A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2- Arachidonoylglycerol (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692834/
Organophosphate-Sensitive Lipases Modulate Brain Lysophospholipids, Ether Lipids and Endocannabinoids (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582404/
Activation of the endocannabinoid system by organophosphorus nerve agents (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597283/
Presence of functional cannabinoid receptors in human endocrine pancreas. (abst – 2008) http://www.frontiersin.org/publications/18092149 Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhi...
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L-a-LYSOPHOSPHATIDYLINOSITOL > 2009-2013
The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation. (full – 2009) http://www.fasebj.org/content/23/1/183.long GPR55 ligands promote receptor coupl...
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HEMOPRESIN > 2007-2014
Hemopressin is an inverse agonist of CB1 cannabinoid receptors (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154475/ Novel endogenous peptide agonists of cannabinoid receptors (full – 2009)...
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FABP / FATTY ACID BINDING PROTEINS > 2014
Inhibition of Fatty Acid binding proteins elevates brain anandamide levels and produces analgesia. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976407/ Inv...
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FAAH / FATTY ACID AMIDE HYDROLASE > 2011-2014
Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/arti...ihms275514.pdf
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/arti...0/?tool=pubmed
A catalytically silent FAAH-1 variant drives anandamide transport in neurons. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245783/
The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans (full – 2011) http://www.lipidworld.com/content/10/1/129
Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. (full – 2011) http://www.jbc.org/content/early/201...10.202853.long
Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21740924 Endocannabinoid regulation of acute and protracted nicotine wi...
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ENDOCANNABINOID SYSTEM* > 2014
Δ(9)-THC and N-arachidonoyl glycine regulate BV-2 microglial morphology and cytokine release plasticity: implications for signaling at GPR18. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877838/
Endocannabinoid Modulation of Cortical Up-States and NREM Sleep (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919802/
Involvement of the Cannabinoid CB1 Receptor in Modulation of Dopamine Output in the Prefrontal Cortex
Associated with Food Restriction in Rats. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954872/
Endocannabinoids are Involved in Male Vertebrate Reproduction: Regulatory Mechanisms at Central and Gonadal Level. (full – 2014) http://journal.frontiersin.org/Journ...014.00054/full
Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953590/
The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages. (full – 2014) http://www.ncbi.nlm.nih...
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SPICE - NEWS
Synthetic cannabis mimic found in herbal incense (news – 2009) http://www.rsc.org/chemistryworld/Ne...y/15010901.asp
Inhaled Incense “K2†May Cause Heart Damage (news – 2010) http://drwes.blogspot.com/2010/08/in...use-heart.html
The New Cannabinoids (news – 2010) http://www.wellsphere.com/drug-addic...inoids/1247426
Outlawing ‘Legal Highs:’ Can Emergency Bans Hinder Drug Development? (news – 2011) http://health...
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SPICE - STUDIES
'Crazy Monkey' Poisons Man and Dog: Human and canine seizures due to PB-22, a novel synthetic cannabinoid (full – 2014)http://informahealthcare.com/doi/ful...50.2014.925562
Emerging Drugs of Abuse: Clinical and Legal Considerations (full – 2014) http://rimed.org/rimedicaljournal/20...psych-aoun.pdf Hair analy...
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SR-144528
p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells (full – 2005)http://www.sciencedirect.com/science...14579305010057
Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor (full – 2006)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1616976/ The CB2 cannabinoid receptor si...
- 1 post