Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. (full – 2001) http://www.jbc.org/content/276/46/42639.long
Regulation of anandamide tissue levels by N-arachidonylglycine. (abst – 2002) http://www.n...
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NAGly / N-ARACHIDDONOYL GLYCINE > 2001-2014
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URB-532
The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity (full – 2005) htt...
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URB-584
...Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats (abst – 2014)http://www.ncbi.nlm.nih.gov/pubmed/24703998
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URB-447
Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats (full – 2013)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659...
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UR-144
URB-754: A new class of designer drug and 12 synthetic cannabinoids detected in illegal products (abst – 2012)http://www.ncbi.nlm.nih.gov/pubmed/23063179
Detection of urinary metabolites of AM-2201 and UR-144, two novel synthetic cannabinoids (abst – 2013)http://www.ncbi...
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TARANABANT / MK-0364
The discovery of taranabant, a selective cannabinoid-1 receptor inverse agonist for the treatment of obesity (full – 2008)http://onlinelibrary.wiley.com/doi/1....200700255/pdf
Taranabant, a novel cannabinoid type 1 receptor inverse agonist (abst – 2008) http://www.ncbi.nlm.nih.gov/pubme...
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TM-38837
Experimental obesity drug avoids brain effects that troubled predecessors (news – 2010) http://phys.org/news197905295.html Low brain CB1 receptor occupancy by a second...
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TAK- 875 / FASIGLIFAM
TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats (full – 2011)http://jpet.aspetjournals.org/content/339/1/228.long Takeda moves potential first-in-cl...
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SURINABANT / SR 147778
SR147778 [5-(4-Bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a New Potent and Selective Antagonist of the CB1 Cannabinoid Receptor: Biochemical and Pharmacological Characterization...
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SR-144528
p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells (full – 2005)http://www.sciencedirect.com/science...14579305010057
Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor (full – 2006)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1616976/ The CB2 cannabinoid receptor si...
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MAGL / MGL / MONOACYLGLYCEROL LIPASE > 2006-2014
Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice. (abst – 2006) http://www.ncbi.nlm.nih.gov/pubmed/16310817
A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2- Arachidonoylglycerol (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692834/
Organophosphate-Sensitive Lipases Modulate Brain Lysophospholipids, Ether Lipids and Endocannabinoids (full – 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582404/
Activation of the endocannabinoid system by organophosphorus nerve agents (full - 2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597283/
Presence of functional cannabinoid receptors in human endocrine pancreas. (abst – 2008) http://www.frontiersin.org/publications/18092149 Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhi...
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L-a-LYSOPHOSPHATIDYLINOSITOL > 2009-2013
The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation. (full – 2009) http://www.fasebj.org/content/23/1/183.long GPR55 ligands promote receptor coupl...
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HEMOPRESIN > 2007-2014
Hemopressin is an inverse agonist of CB1 cannabinoid receptors (full – 2007) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154475/ Novel endogenous peptide agonists of cannabinoid receptors (full – 2009)...
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FABP / FATTY ACID BINDING PROTEINS > 2014
Inhibition of Fatty Acid binding proteins elevates brain anandamide levels and produces analgesia. (full – 2014) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976407/ Inv...
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FAAH / FATTY ACID AMIDE HYDROLASE > 2011-2014
Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/arti...ihms275514.pdf
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/arti...0/?tool=pubmed
A catalytically silent FAAH-1 variant drives anandamide transport in neurons. (full – 2011) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245783/
The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans (full – 2011) http://www.lipidworld.com/content/10/1/129
Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. (full – 2011) http://www.jbc.org/content/early/201...10.202853.long
Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice. (abst – 2011) http://www.ncbi.nlm.nih.gov/pubmed/21740924 Endocannabinoid regulation of acute and protracted nicotine wi...
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